*All release dates are subject to change (and often do).
| Release Date | Set Name |
|---|---|
| 1/4 | 2021 Leaf Metal Draft Baseball |
| 1/6 | 2021 Topps Baseball UK Edition |
| 1/11 | 2021 Topps Chrome Update Series Baseball |
| 1/18 | 2021 Bowman Draft Sapphire Edition Baseball |
| 1/21 | 2021 Leaf Flash Baseball |
| January | 2021 Topps Chrome NPB Baseball |
| 2/11 | 2021 Pro Set Metal Baseball |
| 2/15 | 2022 Topps Series 1 Baseball 1st Edition |
| 2/16 | 2022 Topps Series 1 Baseball |
| 2/16 | 2022 Topps Baseball Silver Pack Chrome Promo |
| 2/16 | 2021 Onyx Gems Baseball |
| 2/24 | 2022 Topps X Aaron Judge Curated Baseball |
| 3/3 | 2021 Leaf Draft Baseball Blaster |
| 3/8 | 2021 Pro Set Baseball Blaster |
| 3/9 | 2022 Topps Opening Day Baseball |
| 3/11 | 2022 Topps Heritage Baseball |
| 3/15 | 2022 Bowman 1st Edition Baseball |
| 3/23 | 2021 Topps Chrome Update Series Sapphire Edition Baseball |
| 3/25 | 2022 Topps Spotlight 70 II By Andy Friedman Baseball |
| 3/30 | 2022 Topps Inception Baseball |
| 4/8 | 2021 Panini Stars & Stripes USA Baseball |
| 4/20 | 2022 Topps Archives Signature Series Active Player Edition Baseball |
| 4/20 | 2021 Topps Big League Baseball |
| 4/22 | 2021 Panini Prizm Draft Picks Baseball |
| 4/29 | 2022 Donruss Baseball |
| April | 2022 Topps Baseball Factory Team Set |
| 5/4 | 2022 Bowman Baseball |
| 5/10 | 2022 Topps Dynamic Duals Baseball |
| 5/11 | 2022 Panini Diamond Kings Baseball |
| 5/11 | 2022 Topps Tribute Baseball |
| 5/13 | 2021 Bowman Chrome Sapphire Edition Baseball |
| 5/17 | 2022 Leaf Stitches & Slabs Baseball |
| 5/18 | 2022 Topps Sterling Baseball |
| 5/20 | 2022 Topps Gypsy Queen Baseball |
| 5/24 | 2022 Bowman Sapphire Edition Baseball |
| 6/1 | 2022 Bowman Mega Box Chrome Baseball |
| 6/10 | 2022 Panini Absolute Baseball |
| 6/10 | 2022 Topps Series 2 Baseball |
| 6/15 | 2022 Onyx Vintage Baseball |
| 6/18 | 2022 Topps X MLB Players Exclusive Baseball Promo |
| 6/24 | 2022 Panini Select Baseball |
| 6/29 | 2021 Topps Chrome Platinum Anniversary Baseball |
| 7/6 | 2022 Topps Definitive Collection Baseball |
| 7/8 | 2021 Leaf Trinity Baseball |
| 7/13 | 2022 Topps Archives Signature Series Retired Player Edition Baseball |
| 7/13 | 2022 Topps Pristine Baseball |
| 7/22 | 2022 Topps Stadium Club Members Only Derek Jeter Baseball |
| 7/27 | 2022 Topps Tier One Baseball |
| 7/27 | 2022 Topps NSCC Bowman Chrome National Convention Wrapper Redemption Baseball |
| 8/3 | 2022 Topps Baseball Complete Factory Set |
| 8/17 | 2022 Topps Diamond Icons Baseball |
| 8/19 | 2022 Leaf Lumber Baseball |
| 8/24 | 2022 Topps Clearly Authentic Baseball |
| 8/25 | 2022 Topps Finest Flashbacks Baseball |
| 8/30 | 2022 Topps 3D Baseball |
| 8/31 | 2022 Topps Fire Baseball |
| 9/7 | 2022 Topps Museum Collection Baseball |
| 9/9 | 2022 Topps NPB Nippon Professional Baseball |
| 9/9 | 2022 Onyx Premium Baseball Cards |
| 9/16 | 2022 Panini Immaculate Collection Baseball |
| 9/16 | 2022 Topps Chrome Baseball |
| 9/30 | 2022 Panini Prizm Baseball |
| 9/30 | 2022 Topps Pro Debut Baseball |
| September | 2022 Fanatics Under Wraps Series 2 Autographed Baseball |
| 10/7 | 2022 Panini Three and Two Baseball |
| 10/12 | 2022 Topps Archives Baseball |
| 10/12 | 2022 Topps Update Series Baseball |
| 10/14 | 2022 Panini Chronicles Baseball |
| 10/19 | 2022 Bowman Sterling Baseball |
| 10/21 | 2022 Topps Luminaries Baseball |
| October | 2021 Leaf Valiant Baseball |
| 11/2 | 2022 Topps Cosmic Chrome Baseball |
| 11/2 | 2022 Topps Gilded Collection Baseball |
| 11/2 | 2022 Topps Stadium Club Baseball |
| 11/4 | 2022 Panini Mosaic Baseball |
| 11/9 | 2022 Topps Heritage Minor League Baseball |
| 11/23 | 2022 Topps Triple Threads Baseball |
| 11/30 | 2022 Bowman Chrome Baseball |
| November | 2022 Topps Allen & Ginter Baseball |
| November | 2022 Bowman Inception Baseball |
| November | 2022 Topps Five Star Baseball |
| November | 2022 Topps Gold Label Baseball |
| November | 2022 Topps Heritage High Number Baseball |
| November | 2022 Onyx Vintage Extended Baseball |
| December | 2022 Topps Finest Baseball |
| TBA | 2021 Bowman Heritage Baseball |